Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle.

Dowman, Joanna K; Hopkins, Laurence J; Reynolds, Gary M; Nikolaou, Nikolaos; Armstrong, Matthew J; Shaw, Jean C; Houlihan, Diarmaid D; Lalor, Patricia F; Tomlinson, Jeremy W; Hübscher, Stefan G; Newsome, Philip N

Dowman, Joanna K; Hopkins, Laurence J; Reynolds, Gary M; Nikolaou, Nikolaos; Armstrong, Matthew J; Shaw, Jean C; Houlihan, Diarmaid D; Lalor, Patricia F; Tomlinson, Jeremy W; Hübscher, Stefan G; Newsome, Philip N.

Afiliação

Dowman JK; Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
Hopkins LJ; Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom. Electronic address: ljh2g13@soton.ac.uk.
Reynolds GM; Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom.
Nikolaou N; Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, United Kingdom.
Armstrong MJ; Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
Shaw JC; Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom.
Houlihan DD; Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
Lalor PF; Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom.
Tomlinson JW; Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, United Kingdom.
Hübscher SG; Department of Cellular Pathology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
Newsome PN; Department of NIHR Liver Biomedical Research Unit and Centre for Liver Research, University of Birmingham, Birmingham, United Kingdom; Liver Unit, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom. Electronic address: p.n.newsome@bham.ac.uk.

Am J Pathol ; 184(5): 1550-61, 2014 May.

Article em En | MEDLINE | ID: mdl-24650559

Assuntos

Carcinoma Hepatocelular/complicações; Carcinoma Hepatocelular/patologia; Dieta Hiperlipídica/efeitos adversos; Frutose/efeitos adversos; Neoplasias Hepáticas/patologia; Hepatopatia Gordurosa não Alcoólica/complicações; Hepatopatia Gordurosa não Alcoólica/patologia; Animais; Carcinoma Hepatocelular/irrigação sanguínea; Modelos Animais de Doenças; Regulação da Expressão Gênica; Humanos; Insulina/metabolismo; Metabolismo dos Lipídeos/genética; Fígado/lesões; Fígado/metabolismo; Fígado/patologia; Neoplasias Hepáticas/complicações; Masculino; Camundongos Endogâmicos C57BL; Hepatopatia Gordurosa não Alcoólica/genética; Obesidade/complicações; Obesidade/patologia; Fatores de Transcrição SOX9/metabolismo; Comportamento Sedentário; Transdução de Sinais/genética; Células-Tronco/patologia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Dieta Hiperlipídica / Hepatopatia Gordurosa não Alcoólica / Frutose / Neoplasias Hepáticas Idioma: En Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google