Folates are potential ligands for ruthenium compounds in vivo.
Dalton Trans
; 43(22): 8158-61, 2014 Jun 14.
Article
em En
| MEDLINE
| ID: mdl-24695679
ABSTRACT
Under physiologically relevant conditions, cis-bis(2,2'-bipyridine)dichlororuthenium(II), [cis-Ru(2,2'-bipy)2Cl2] was observed to bind to folic acid via replacement of the two chloride ligands. This binding was shown to be pH dependent and afforded diastereomers, the structures of which were determined by 1- and 2D NMR spectroscopic techniques. We propose that when studying the cytotoxicity of labile ruthenium complexes in cells, folate coordination should be considered.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Rutênio
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Ácido Fólico
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article