Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS).
ACS Med Chem Lett
; 1(2): 59-63, 2010 May 13.
Article
em En
| MEDLINE
| ID: mdl-24900177
ABSTRACT
Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In this letter, we report the discovery of an orally potent and selective inhibitor of HPGDS that reduces the antigen-induced response in allergic sheep.
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MEDLINE
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En
Ano de publicação:
2010
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Article