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Characterisation of familial colorectal cancer Type X, Lynch syndrome, and non-familial colorectal cancer.
Shiovitz, S; Copeland, W K; Passarelli, M N; Burnett-Hartman, A N; Grady, W M; Potter, J D; Gallinger, S; Buchanan, D D; Rosty, C; Win, A K; Jenkins, M; Thibodeau, S N; Haile, R; Baron, J A; Marchand, L L; Newcomb, P A; Lindor, N M.
Afiliação
  • Shiovitz S; 1] Department of Medicine, University of Washington, Seattle, WA, USA [2] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Copeland WK; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Passarelli MN; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Burnett-Hartman AN; 1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Grady WM; 1] Department of Medicine, University of Washington, Seattle, WA, USA [2] Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [3] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Potter JD; 1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Epidemiology, University of Washington, Seattle, WA, USA [3] Centre for Public Health Research, Massey University, Wellington, New Zealand.
  • Gallinger S; Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
  • Buchanan DD; 1] University of Melbourne, Parkville, VIC, Australia [2] Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, QLD, Australia.
  • Rosty C; 1] Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, QLD, Australia [2] University of Queensland, School of Medicine, Herston, QLD, Australia [3] Envoi Pathology, Herston, QLD, Australia.
  • Win AK; University of Melbourne, Parkville, VIC, Australia.
  • Jenkins M; University of Melbourne, Parkville, VIC, Australia.
  • Thibodeau SN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Haile R; Stanford Cancer Institute, Palo Alto, CA, USA.
  • Baron JA; Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
  • Marchand LL; University of Hawaii Cancer Center, Honolulu, HI, USA.
  • Newcomb PA; 1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA [2] Department of Epidemiology, University of Washington, Seattle, WA, USA.
  • Lindor NM; Department of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA.
Br J Cancer ; 111(3): 598-602, 2014 Jul 29.
Article em En | MEDLINE | ID: mdl-24918813
ABSTRACT

BACKGROUND:

Familial Colorectal Cancer Type X (FCCTX) is defined as individuals with colorectal cancer (CRC) who families meet Amsterdam Criteria-1 (AC1), but whose tumours are DNA-mismatch-repair-proficient, unlike Lynch syndrome (LS). FCCTX does not have an increased risk of extra-colonic cancers. This analysis compares epidemiologic and clinicopathologic features among FCCTX, LS, and 'non-familial' (non-AC1) CRC cases.

METHODS:

From the Colon Cancer Family Registry, FCCTX (n=173), LS (n=303), and non-AC1 (n=9603) CRC cases were identified. Questionnaire-based epidemiologic information and CRC pathologic features were compared across case groups using polytomous logistic regression.

RESULTS:

Compared with LS, FCCTX cases were less likely to be current (vs never) smokers; have a proximal subsite (vs rectal) tumour; or have mucinous histology, poor differentiation, or tumour-infiltrating lymphocytes. There were no observed differences in co-morbidities or medication usage.

CONCLUSIONS:

FCCTX were less likely to be current tobacco users; other exposures were similar between these groups. Histopathologic differences highly suggestive of LS CRCs do not appear to be shared by FCCTX.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais Hereditárias sem Polipose / Neoplasias Císticas, Mucinosas e Serosas Idioma: En Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais Hereditárias sem Polipose / Neoplasias Císticas, Mucinosas e Serosas Idioma: En Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos