NAT2, XRCC1 and hOGG1 polymorphisms, cigarette smoking, alcohol consumption and risk of upper aerodigestive tract cancer.
Anticancer Res
; 34(6): 3217-24, 2014 Jun.
Article
em En
| MEDLINE
| ID: mdl-24922697
ABSTRACT
AIM:
To evaluate associations between polymorphisms of the N-acetyltransferase 2 (NAT2), human 8-oxoguanine glycosylase 1 (hOGG1) and X-ray repair cross-complementing protein 1 (XRCC1) genes and risk of upper aerodigestive tract (UADT) cancer. PATIENTS ANDMETHODS:
A case-control study involving 117 cases and 224 controls was undertaken. The NAT2 gene polymorphisms were genotyped by automated sequencing and XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms were determined by Polymerase Chain Reaction followed by Restriction Fragment Length Polymorphism (PCR-RFLP) methods.RESULTS:
Slow metabolization phenotype was significantly associated as a risk factor for the development of UADT cancer (p=0.038). Furthermore, haplotype of slow metabolization was also associated with UADT cancer (p=0.014). The hOGG1 Ser326Cys polymorphism (CG or GG vs. CC genotypes) was shown as a protective factor against UADT cancer in moderate smokers (p=0.031). The XRCC1 Arg399Gln polymorphism (GA or AA vs. GG genotypes), in turn, was a protective factor against UADT cancer only among never-drinkers (p=0.048).CONCLUSION:
Interactions involving NAT2, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms may modulate the risk of UADT cancer in this population.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Arilamina N-Acetiltransferase
/
Neoplasias do Sistema Respiratório
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Consumo de Bebidas Alcoólicas
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Fumar
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Polimorfismo de Nucleotídeo Único
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DNA Glicosilases
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Proteínas de Ligação a DNA
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Neoplasias Gastrointestinais
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil