The role of HE4 in ovarian cancer follow-up: a review.
Int J Gynecol Cancer
; 24(8): 1359-65, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25054447
ABSTRACT
OBJECTIVE:
The aim of this review was to analyze the state of the art about HE4 and follow-up in patients treated for ovarian cancer.METHODS:
A literature search was conducted in the MEDLINE database using the key words "HE4" and "ovarian cancer" and "recurrence" or "relapse" or "follow up."RESULTS:
Seven of 28 clinical studies were selected. Four studies were prospective, and all of them were based on a small number of patients (8-73 women). A failure of HE4 levels to normalize at completion of standard therapy may indicate a poor prognosis, thus suggesting the need of a closer follow-up. Moreover, HE4 showed better sensibility and specificity in the diagnosis of ovarian cancer recurrence with respect to CA-125, being also an earlier indicator of the relapse with a lead time of 5 to 8 months. HE4 showed a better performance in this setting if performed in association with other markers (CA-125, CA-72.4). HE4 seems to be an independent predictive factor for the surgical outcome at secondary cytoreductive surgery and to maintain its prognostic role even after the recurrence.CONCLUSIONS:
These preliminary data start to suggest a superiority of HE4 over CA-125 in the detection of ovarian cancer recurrence. Moreover, the prognostic role of HE4 could help clinicians to personalize the follow-up program, whereas its predictive role could be useful to plan the treatment of the relapse. The role of HE4 in ovarian cancer follow-up deserves to be further investigated in prospective randomized multicentric studies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
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Proteínas
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Biomarcadores Tumorais
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Monitorização Fisiológica
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article