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Discovery of novel non-carboxylic acid 5-amino-4-cyanopyrazole derivatives as potent and highly selective LPA1R antagonists.
Sidduri, Achyutharao; Budd, David C; Fuentes, Maria E; Lambros, Ted; Ren, Yonglin; Roongta, Vikram; Schoenfeld, Ryan C; Gillespie, Paul; Stevenson, Christopher S; Truitt, Theresa; Qian, Yimin.
Afiliação
  • Sidduri A; Discovery Chemistry, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA. Electronic address: sidduri@aunovamedchem.com.
  • Budd DC; Inflammation Discovery and Translational Area, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
  • Fuentes ME; Inflammation Discovery and Translational Area, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
  • Lambros T; Discovery Chemistry, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
  • Ren Y; Inflammation Discovery and Translational Area, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
  • Roongta V; Discovery Chemistry, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
  • Schoenfeld RC; Discovery Chemistry, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
  • Gillespie P; Discovery Chemistry, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
  • Stevenson CS; Inflammation Discovery and Translational Area, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
  • Truitt T; Discovery Technology, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
  • Qian Y; Discovery Chemistry, Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, NJ 07110, USA.
Bioorg Med Chem Lett ; 24(18): 4450-4454, 2014 Sep 15.
Article em En | MEDLINE | ID: mdl-25155385
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Receptores de Ácidos Lisofosfatídicos / Descoberta de Drogas Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Receptores de Ácidos Lisofosfatídicos / Descoberta de Drogas Idioma: En Ano de publicação: 2014 Tipo de documento: Article