Cation-chloride cotransporters in neuronal development, plasticity and disease.
Nat Rev Neurosci
; 15(10): 637-54, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25234263
Electrical activity in neurons requires a seamless functional coupling between plasmalemmal ion channels and ion transporters. Although ion channels have been studied intensively for several decades, research on ion transporters is in its infancy. In recent years, it has become evident that one family of ion transporters, cation-chloride cotransporters (CCCs), and in particular K(+)-Cl(-) cotransporter 2 (KCC2), have seminal roles in shaping GABAergic signalling and neuronal connectivity. Studying the functions of these transporters may lead to major paradigm shifts in our understanding of the mechanisms underlying brain development and plasticity in health and disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Doenças do Sistema Nervoso Central
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Simportadores de Cloreto de Sódio-Potássio
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Plasticidade Neuronal
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Neurônios
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Finlândia