[Carriers of haemophilia: Experience of a French university hospital]. / Conductrices d'hémophilie: expérience d'un CHRU en France.
J Gynecol Obstet Biol Reprod (Paris)
; 44(6): 565-76, 2015 Jun.
Article
em Fr
| MEDLINE
| ID: mdl-25263159
ABSTRACT
OBJECTIVES:
To report the management of carriers of haemophilia in a French university hospital and assess different issues of these patients. PATIENTS ANDMETHODS:
Retrospective study of the carriers of haemophilia who consulted at the university hospital of Montpellier, France, between 1995 and 2011. Information were obtained from medical records and from a questionnaire sent to carriers. We recorded data about biological characteristics, bleeding tendency and management of pregnancies.RESULTS:
Sixty-four carriers of haemophilia A or B were included. Their median FVIII or FIX level was 52 % (range, 15-137 %). Menstrual bleeding lasted more than 7 days in 31 % of carriers. A total of 142 pregnancies started in 54 carriers, and 101 resulted in live births with 26 boys with haemophilia. Sixty-two prenatal diagnoses carried out, 15 have terminated their pregnancy because of a hemophiliac male fetus. Seventy-six percent of deliveries were vaginal delivery and 49 % took place in a level-3 maternity. There were 10.8 % and 8.5 % primary and secondary post-partum hemorrhage, respectively.CONCLUSION:
The risk of bleeding among carriers of haemophilia is associated with their antihemophilic factor level. To improve the management of carriers, a multidisciplinary and standardized medical record, with a specific questionnaire to evaluate bleedings, could be considered. A regional register that lists all carriers, regardless of their antihemophilic factor level, would also be useful.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações Hematológicas na Gravidez
/
Resultado da Gravidez
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Hemofilia B
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Hemofilia A
País/Região como assunto:
Europa
Idioma:
Fr
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
França