Desmosomal defects in acantholytic squamous cell carcinomas.
J Cutan Pathol
; 41(11): 873-9, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25264142
ABSTRACT
BACKGROUND:
Acantholytic squamous cell carcinoma (Acantholytic SCC) are epithelial tumors characterized by a loss of cell adhesion between neoplastic keratinocytes. The mechanism underlying loss of cell-cell adhesion in these tumors is not understood.METHODS:
A retrospective analysis of acantholytic SCC (n = 17) and conventional SCC (n = 16, controls not showing acantholysis) was conducted using a set of desmosomal and adherens junction protein antibodies. Immunofluorescence microscopy was used to identify tumors with loss of adhesion protein expression.RESULTS:
The vast majority of acantholytic SCC (89%) showed focal loss of at least one desmosomal cell adhesion protein. Most interestingly, 65% of these tumors lost expression of two or more desmosomal proteins.CONCLUSIONS:
Loss of cell adhesion in acantholytic SCC is most likely linked to the focal loss of desmosomal protein expression, thus providing potential mechanistic insight into the patho-mechanism underlying this malignancy.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Carcinoma de Células Escamosas
/
Acantólise
/
Desmossomos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos