Genetic profile of T-cell acute lymphoblastic leukemias with MYC translocations.
Blood
; 124(24): 3577-82, 2014 Dec 04.
Article
em En
| MEDLINE
| ID: mdl-25270907
ABSTRACT
MYC translocations represent a genetic subtype of T-lineage acute lymphoblastic leukemia (T-ALL), which occurs at an incidence of â¼6%, assessed within a cohort of 196 T-ALL patients (64 adults and 132 children). The translocations were of 2 types; those rearranged with the T-cell receptor loci and those with other partners. MYC translocations were significantly associated with the TAL/LMO subtype of T-ALL (P = .018) and trisomies 6 (P < .001) and 7 (P < .001). Within the TAL/LMO subtype, gene expression profiling identified 148 differentially expressed genes between patients with and without MYC translocations; specifically, 77 were upregulated and 71 downregulated in those with MYC translocations. The poor prognostic marker, CD44, was among the upregulated genes. MYC translocations occurred as secondary abnormalities, present in subclones in one-half of the cases. Longitudinal studies indicated an association with induction failure and relapse.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
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Regulação Neoplásica da Expressão Gênica
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Proteínas Proto-Oncogênicas c-myc
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Leucemia-Linfoma Linfoblástico de Células T Precursoras
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article