Role of the ubiquitin-proteasome system in cardiac dysfunction of adipose triglyceride lipase-deficient mice.

Mussbacher, Marion; Stessel, Heike; Wölkart, Gerald; Haemmerle, Guenter; Zechner, Rudolf; Mayer, Bernd; Schrammel, Astrid

Mussbacher, Marion; Stessel, Heike; Wölkart, Gerald; Haemmerle, Guenter; Zechner, Rudolf; Mayer, Bernd; Schrammel, Astrid.

Afiliação

Mussbacher M; Department of Pharmacology and Toxicology, University of Graz, Universitätsplatz 2, A-8010 Graz, Austria. Electronic address: marion.mussbacher@uni-graz.at.
Stessel H; Department of Pharmacology and Toxicology, University of Graz, Universitätsplatz 2, A-8010 Graz, Austria. Electronic address: heike.stessel@uni-graz.at.
Wölkart G; Department of Pharmacology and Toxicology, University of Graz, Universitätsplatz 2, A-8010 Graz, Austria. Electronic address: gerald.woelkart@uni-graz.at.
Haemmerle G; Department of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A-8010 Graz, Austria. Electronic address: guenter.haemmerle@uni-graz.at.
Zechner R; Department of Molecular Biosciences, University of Graz, Heinrichstrasse 31, A-8010 Graz, Austria. Electronic address: rudolf.zechner@uni-graz.at.
Mayer B; Department of Pharmacology and Toxicology, University of Graz, Universitätsplatz 2, A-8010 Graz, Austria. Electronic address: mayer@uni-graz.at.
Schrammel A; Department of Pharmacology and Toxicology, University of Graz, Universitätsplatz 2, A-8010 Graz, Austria. Electronic address: astrid.schrammel-gorren@uni-graz.at.

J Mol Cell Cardiol ; 77: 11-9, 2014 Dec.

Article em En | MEDLINE | ID: mdl-25285770

Assuntos

Cardiomiopatias/enzimologia; Lipase/deficiência; Complexo de Endopeptidases do Proteassoma/metabolismo; Ubiquitinação; Animais; Apoptose; Estresse do Retículo Endoplasmático; Feminino; Expressão Gênica; Técnicas de Inativação de Genes; Lipase/genética; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Miocárdio/metabolismo; NF-kappa B/metabolismo; Estresse Oxidativo; PPAR alfa/agonistas; PPAR alfa/metabolismo; Proteólise; Pirimidinas/farmacologia; Transdução de Sinais; Proteínas Ubiquitinadas/metabolismo

Palavras-chave

Adipose triglyceride lipase; Cardiac dysfunction; Inflammation; NF-κB; Peroxisome proliferator-activated receptor α

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complexo de Endopeptidases do Proteassoma / Ubiquitinação / Lipase / Cardiomiopatias Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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