Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.

Shibata, Shigeru; Arroyo, Juan Pablo; Castañeda-Bueno, María; Puthumana, Jeremy; Zhang, Junhui; Uchida, Shunya; Stone, Kathryn L; Lam, TuKiet T; Lifton, Richard P

Shibata, Shigeru; Arroyo, Juan Pablo; Castañeda-Bueno, María; Puthumana, Jeremy; Zhang, Junhui; Uchida, Shunya; Stone, Kathryn L; Lam, TuKiet T; Lifton, Richard P.

Afiliação

Shibata S; Departments of Genetics and Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8605, Japan; and Department of Clinical Epigenetics, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153-0041, Japan Howard Hughes Medi
Arroyo JP; Departments of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;
Castañeda-Bueno M; Departments of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;
Puthumana J; Departments of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;
Zhang J; Departments of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;
Uchida S; Division of Nephrology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8605, Japan; and.
Stone KL; Molecular Biophysics and Biochemistry and.
Lam TT; Molecular Biophysics and Biochemistry and.
Lifton RP; Departments of Genetics and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510; richard.lifton@yale.edu shigeru.shibata@med.teikyo-u.ac.jp.

Proc Natl Acad Sci U S A ; 111(43): 15556-61, 2014 Oct 28.

Article em En | MEDLINE | ID: mdl-25313067

Assuntos

Angiotensina II/metabolismo; Proteínas de Transporte/metabolismo; Proteína Quinase C/metabolismo; Proteínas Serina-Treonina Quinases/metabolismo; Proteólise; Transdução de Sinais; Proteínas Adaptadoras de Transdução de Sinal; Sequência de Aminoácidos; Animais; Proteínas de Transporte/química; Linhagem Celular; Humanos; Rim/metabolismo; Camundongos Endogâmicos C57BL; Proteínas dos Microfilamentos; Dados de Sequência Molecular; Fosforilação; Fosfosserina/metabolismo; Ligação Proteica

Palavras-chave

PHAII; distal tubule; hypertension; posttranslational modification; reninangiotensinaldosterone system

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Quinase C / Angiotensina II / Transdução de Sinais / Proteínas de Transporte / Proteínas Serina-Treonina Quinases / Proteólise Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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