A randomized, double blind pilot study to assess the effects of losartan vs. atenolol on the biophysical properties of the aorta in patients with Marfan and Loeys-Dietz syndromes.

Sandor, George G S; Alghamdi, Mohammed H; Raffin, Leslie A; Potts, Mary T; Williams, Lindsey D; Potts, James E; Kiess, Marla; van Breemen, Casey

Sandor, George G S; Alghamdi, Mohammed H; Raffin, Leslie A; Potts, Mary T; Williams, Lindsey D; Potts, James E; Kiess, Marla; van Breemen, Casey.

Afiliação

Sandor GG; Children's Heart Centre, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada. Electronic address: gsandor@cw.bc.ca.
Alghamdi MH; Children's Heart Centre, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.
Raffin LA; Children's Heart Centre, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.
Potts MT; Children's Heart Centre, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.
Williams LD; Children's Heart Centre, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.
Potts JE; Children's Heart Centre, British Columbia Children's Hospital, The University of British Columbia, Vancouver, Canada.
Kiess M; Division of Cardiology, Department of Medicine, St. Paul's Hospital, The University of British Columbia, Vancouver, Canada.
van Breemen C; Department of Pharmacology and Therapeutics, The University of British Columbia, Vancouver, Canada.

Int J Cardiol ; 179: 470-5, 2015 Jan 20.

Article em En | MEDLINE | ID: mdl-25465809

Assuntos

Antagonistas de Receptores Adrenérgicos beta 1/uso terapêutico; Bloqueadores do Receptor Tipo 1 de Angiotensina II/uso terapêutico; Aorta/efeitos dos fármacos; Aorta/fisiopatologia; Atenolol/uso terapêutico; Síndrome de Loeys-Dietz/tratamento farmacológico; Síndrome de Loeys-Dietz/fisiopatologia; Losartan/uso terapêutico; Síndrome de Marfan/tratamento farmacológico; Síndrome de Marfan/fisiopatologia; Adolescente; Método Duplo-Cego; Ecocardiografia; Endotélio Vascular/efeitos dos fármacos; Endotélio Vascular/fisiopatologia; Feminino; Humanos; Masculino; Projetos Piloto; Análise de Onda de Pulso; Resultado do Tratamento

Palavras-chave

Atenolol; Clinical trial; LoeysDietz syndrome; Losartan; Marfan syndrome; Vascular function

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aorta / Atenolol / Losartan / Bloqueadores do Receptor Tipo 1 de Angiotensina II / Síndrome de Loeys-Dietz / Antagonistas de Receptores Adrenérgicos beta 1 / Síndrome de Marfan Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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