Dynamics of cell area and force during spreading.
Biophys J
; 107(12): L37-L40, 2014 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-25517168
ABSTRACT
Experiments on human pulmonary artery endothelial cells are presented to show that cell area and the force exerted on a substrate increase simultaneously, but with different rates during spreading; rapid-force increase systematically occurred several minutes past initial spreading. We examine this theoretically and present three complementary mechanisms that may accompany the development of lamellar stress during spreading and underlie the observed behavior. These include 1), the dynamics of cytoskeleton assembly at the cell basis; 2), the strengthening of acto-myosin forces in response to the generated lamellar stresses; and 3), the passive strain-stiffening of the cytoskeleton.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pseudópodes
/
Citoesqueleto
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Movimento Celular
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Células Endoteliais
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Modelos Biológicos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Israel