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Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.
Yang, Jun; Charif, Andrea C; Puskas, Judit E; Phillips, Hannah; Shanahan, Kaitlyn J; Garsed, Jessica; Fleischman, Aaron; Goldman, Ken; Roy, Shuvo; Luebbers, Matthew T; Dombrowski, Stephen M; Luciano, Mark G.
Afiliação
  • Yang J; Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
  • Charif AC; Department of Chemical and Biomolecular Engineering, the University of Akron, USA; Department of Polymer Science, the University of Akron, USA.
  • Puskas JE; Department of Chemical and Biomolecular Engineering, the University of Akron, USA; Department of Polymer Science, the University of Akron, USA.
  • Phillips H; Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
  • Shanahan KJ; Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
  • Garsed J; Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
  • Fleischman A; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
  • Goldman K; H-Cubed, Inc., Olmsted Falls, OH 44138, USA.
  • Luebbers MT; Department of Chemical and Biomolecular Engineering, the University of Akron, USA.
  • Dombrowski SM; Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
  • Luciano MG; Department of Neurosurgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, S60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: lucianm@ccf.org.
J Mech Behav Biomed Mater ; 45: 83-9, 2015 May.
Article em En | MEDLINE | ID: mdl-25688030
ABSTRACT
This study investigated the biocompatibility of the experimental thermoplastic rubber Arbomatrix(™) that will be used as the protective coating on a novel intracranial pressure (ICP) sensor silicon chip. Arbomatrix(™) was benchmarked against biocompatible commercial silicone rubber shunt tubing in the brain via a rat model with 60-day implant duration. A bare silicon chip was also implanted. The results showed similar cellular distribution in the brain-implant boundary and surrounding tissues. Quantitative analysis of neuron and glia density did not show significant difference between implants. Through histological and immunohistochemical evaluation we conclude that Arbomatrix(™) is well tolerated by the brain. Due to its exceptional barrier properties Arbomatrix(™) has already been shown to be an excellent protective coating for new ICP monitoring chip.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plásticos / Borracha / Telemetria / Temperatura / Teste de Materiais / Pressão Intracraniana / Tecnologia sem Fio Idioma: En Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plásticos / Borracha / Telemetria / Temperatura / Teste de Materiais / Pressão Intracraniana / Tecnologia sem Fio Idioma: En Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos