C-peptide as a risk factor of coronary artery disease in the general population.
Diab Vasc Dis Res
; 12(3): 199-207, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25696117
ABSTRACT
OBJECTIVE:
To analyse the association between serum C-peptide and coronary artery disease in the general population.METHODS:
Follow-up study of 6630 adults from the general population. They were stratified into group 1 (no insulin resistance C-peptide < third tercile and glycaemia < 100 mg/dL), group 2 (initial insulin resistance C-peptide ⩾ third tercile and glycaemia < 100 mg/dL) and group 3 (advanced insulin resistance glycaemia ⩾ 100 mg/dL).RESULTS:
After 3.5 years of follow-up, group 2 had a higher incidence of myocardial infarction (relative risk (RR) = 4.2, 95% confidence interval (CI) = 1.7-10.6) and coronary artery disease (RR = 3.5, 95% CI = 1.9-6.6) than group 1. Group 3 also had increased incidences of both diseases. In multivariable analysis of the entire population, groups 2 and 3 showed significant risks of myocardial infarction and coronary artery disease (RR > 3 and RR > 2, respectively). However, when people with diabetes were excluded, the increased risks were corroborated only in group 2 for myocardial infarction (RR = 2.8, 95% CI = 1.1-6.9; p = 0.025) and coronary artery disease (RR = 2.4, 95% CI = 1.3-4.6; p = 0.007).CONCLUSION:
Elevated C-peptide is associated with the incidence of myocardial infarction and coronary artery disease in the general population. It can be an earlier predictor of coronary events than impaired fasting glucose.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Peptídeo C
/
Infarto do Miocárdio
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Espanha