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Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core.
Sivaprakasam, Prasanna; Han, Xiaojun; Civiello, Rita L; Jacutin-Porte, Swanee; Kish, Kevin; Pokross, Matt; Lewis, Hal A; Ahmed, Nazia; Szapiel, Nicolas; Newitt, John A; Baldwin, Eric T; Xiao, Hong; Krause, Carol M; Park, Hyunsoo; Nophsker, Michelle; Lippy, Jonathan S; Burton, Catherine R; Langley, David R; Macor, John E; Dubowchik, Gene M.
Afiliação
  • Sivaprakasam P; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. Electronic address: prasanna.siva@bms.com.
  • Han X; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. Electronic address: xiaojun.han@bms.com.
  • Civiello RL; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Jacutin-Porte S; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Kish K; Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543, USA.
  • Pokross M; Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543, USA.
  • Lewis HA; Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543, USA.
  • Ahmed N; Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543, USA.
  • Szapiel N; Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543, USA.
  • Newitt JA; Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543, USA.
  • Baldwin ET; Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543, USA.
  • Xiao H; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Krause CM; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Park H; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Nophsker M; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Lippy JS; Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, NJ 08543, USA.
  • Burton CR; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Langley DR; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Macor JE; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
  • Dubowchik GM; Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA.
Bioorg Med Chem Lett ; 25(9): 1856-63, 2015 May 01.
Article em En | MEDLINE | ID: mdl-25845281
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridonas / Pirróis / Quinase 3 da Glicogênio Sintase / Inibidores de Proteínas Quinases / Descoberta de Drogas / Aminopiridinas Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridonas / Pirróis / Quinase 3 da Glicogênio Sintase / Inibidores de Proteínas Quinases / Descoberta de Drogas / Aminopiridinas Idioma: En Ano de publicação: 2015 Tipo de documento: Article