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Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase.
Rising, Kathleen A; Crenshaw, Charisse M; Koo, Hyun Jo; Subramanian, Thangaiah; Chehade, Kareem A H; Starks, Courtney; Allen, Keith D; Andres, Douglas A; Spielmann, H Peter; Noel, Joseph P; Chappell, Joe.
Afiliação
  • Rising KA; †Departments of Pharmaceutical Sciences, ‡Cellular and Molecular Biochemistry, §Chemistry, ⊥Center for Structural Biology, ∥Markey Cancer Center, University of Kentucky, Lexington, Lexington, Kentucky, United States.
  • Crenshaw CM; ∇Howard Hughes Medical Institute, Salk Institute, La Jolla, California 92037, United States.
  • Koo HJ; †Departments of Pharmaceutical Sciences, ‡Cellular and Molecular Biochemistry, §Chemistry, ⊥Center for Structural Biology, ∥Markey Cancer Center, University of Kentucky, Lexington, Lexington, Kentucky, United States.
  • Subramanian T; ∇Howard Hughes Medical Institute, Salk Institute, La Jolla, California 92037, United States.
  • Chehade KA; †Departments of Pharmaceutical Sciences, ‡Cellular and Molecular Biochemistry, §Chemistry, ⊥Center for Structural Biology, ∥Markey Cancer Center, University of Kentucky, Lexington, Lexington, Kentucky, United States.
  • Starks C; ∇Howard Hughes Medical Institute, Salk Institute, La Jolla, California 92037, United States.
  • Allen KD; †Departments of Pharmaceutical Sciences, ‡Cellular and Molecular Biochemistry, §Chemistry, ⊥Center for Structural Biology, ∥Markey Cancer Center, University of Kentucky, Lexington, Lexington, Kentucky, United States.
  • Andres DA; ∇Howard Hughes Medical Institute, Salk Institute, La Jolla, California 92037, United States.
  • Spielmann HP; †Departments of Pharmaceutical Sciences, ‡Cellular and Molecular Biochemistry, §Chemistry, ⊥Center for Structural Biology, ∥Markey Cancer Center, University of Kentucky, Lexington, Lexington, Kentucky, United States.
  • Noel JP; ∇Howard Hughes Medical Institute, Salk Institute, La Jolla, California 92037, United States.
  • Chappell J; †Departments of Pharmaceutical Sciences, ‡Cellular and Molecular Biochemistry, §Chemistry, ⊥Center for Structural Biology, ∥Markey Cancer Center, University of Kentucky, Lexington, Lexington, Kentucky, United States.
ACS Chem Biol ; 10(7): 1729-36, 2015 Jul 17.
Article em En | MEDLINE | ID: mdl-25897591
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatos de Poli-Isoprenil / Sesquiterpenos / Nicotiana / Alquil e Aril Transferases / Compostos Macrocíclicos / Alcaloides Idioma: En Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatos de Poli-Isoprenil / Sesquiterpenos / Nicotiana / Alquil e Aril Transferases / Compostos Macrocíclicos / Alcaloides Idioma: En Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos