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Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia.
Abu-Arja, Rolla F; Chernin, Leah R; Abusin, Ghada; Auletta, Jeffery; Cabral, Linda; Egler, Rachel; Ochs, Hans D; Torgerson, Troy R; Lopez-Guisa, Jesus; Hostoffer, Robert W; Tcheurekdjian, Haig; Cooke, Kenneth R.
Afiliação
  • Abu-Arja RF; Pediatric Blood and Marrow Transplant Program, Nationwide Children's Hospital, Columbus, Ohio.
  • Chernin LR; Allergy/Immunology Associates, Inc., Case Western Reserve University, Cleveland, Ohio.
  • Abusin G; Pediatric Bone Marrow Transplant Program, University of Iowa Children's Hospital, Iowa City, Iowa.
  • Auletta J; Pediatric Blood and Marrow Transplant Program, Nationwide Children's Hospital, Columbus, Ohio.
  • Cabral L; Pediatric Bone Marrow Transplant, Rainbow Babies and Children's Hospital, Case Medical Center, Cleveland, Ohio.
  • Egler R; Pediatric Bone Marrow Transplant, Rainbow Babies and Children's Hospital, Case Medical Center, Cleveland, Ohio.
  • Ochs HD; University of Washington and Seattle Children's Research Institute, Seattle, Washington.
  • Lopez-Guisa J; University of Washington and Seattle Children's Research Institute, Seattle, Washington.
  • Hostoffer RW; Allergy/Immunology Associates, Inc., Case Western Reserve University, Cleveland, Ohio.
  • Tcheurekdjian H; Allergy/Immunology Associates, Inc., Case Western Reserve University, Cleveland, Ohio.
  • Cooke KR; Pediatric Blood and Marrow Transplant, Sidney Kimmel Cancer Center, Johns Hopkins University, Baltimore, Maryland.
Pediatr Blood Cancer ; 62(9): 1674-6, 2015 Sep.
Article em En | MEDLINE | ID: mdl-25900577
ABSTRACT
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19(+) B-cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Agamaglobulinemia / Doenças Genéticas Ligadas ao Cromossomo X / Transplante de Células-Tronco de Sangue Periférico Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Agamaglobulinemia / Doenças Genéticas Ligadas ao Cromossomo X / Transplante de Células-Tronco de Sangue Periférico Idioma: En Ano de publicação: 2015 Tipo de documento: Article