Time to symptom improvement using elimination diets in non-IgE-mediated gastrointestinal food allergies.
Pediatr Allergy Immunol
; 26(5): 403-8, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25963794
ABSTRACT
BACKGROUND:
The prevalence of food allergy has increased in recent decades, and there is paucity of data on time to symptom improvement using elimination diets in non-Immunoglobulin E (IgE)-mediated food allergies. We therefore aimed to assess the time required to improvement of symptoms using a symptom questionnaire for children with non-IgE-mediated food allergies on an elimination diet.METHODS:
A prospective observational study was performed on patients with non-IgE-mediated gastrointestinal food allergies on an elimination diet, who completed a questionnaire that includes nine evidence-based food allergic symptoms before and after the exclusion diet. The questionnaire measured symptoms individually from 0 (no symptom) to 5 (most severe) and collectively from 0 to 45. Children were only enrolled in the study if collectively symptoms improved with the dietary elimination within 4 or 8 weeks.RESULTS:
Data from 131 patients were analysed including 90 boys with a median age of 21 months [IQR 7 to 66]. Based on the symptom questionnaire, 129 patients (98.4%) improved after 4-week elimination diet and only two patients improved after 8 weeks. A statistically significant difference before and after commencing the elimination diet was seen in all nine recorded symptoms (all p < 0.001), and in the median of overall score (p < 0.001).CONCLUSION:
This is the first study attempting to establish time to improve after commencing the diet elimination. Almost all children in this study improved within 4 weeks of following the elimination diet, under dietary supervision.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipersensibilidade Alimentar
/
Gastroenteropatias
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Reino Unido