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Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.
Stehouwer, Jeffrey S; Birnbaum, Matthew S; Voll, Ronald J; Owens, Michael J; Plott, Susan J; Bourke, Chase H; Wassef, Michael A; Kilts, Clinton D; Goodman, Mark M.
Afiliação
  • Stehouwer JS; Center for Systems Imaging, Department of Radiology and Imaging Sciences, Emory University, WWHC 209, 1841 Clifton Rd NE, Atlanta, GA 30329, USA. Electronic address: jstehou@emory.edu.
  • Birnbaum MS; Center for Systems Imaging, Department of Radiology and Imaging Sciences, Emory University, WWHC 209, 1841 Clifton Rd NE, Atlanta, GA 30329, USA.
  • Voll RJ; Center for Systems Imaging, Department of Radiology and Imaging Sciences, Emory University, WWHC 209, 1841 Clifton Rd NE, Atlanta, GA 30329, USA.
  • Owens MJ; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
  • Plott SJ; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
  • Bourke CH; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
  • Wassef MA; Center for Systems Imaging, Department of Radiology and Imaging Sciences, Emory University, WWHC 209, 1841 Clifton Rd NE, Atlanta, GA 30329, USA.
  • Kilts CD; Department of Psychiatry and Behavioral Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  • Goodman MM; Center for Systems Imaging, Department of Radiology and Imaging Sciences, Emory University, WWHC 209, 1841 Clifton Rd NE, Atlanta, GA 30329, USA; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Bioorg Med Chem ; 23(15): 4286-4302, 2015 Aug 01.
Article em En | MEDLINE | ID: mdl-26145817
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radioisótopos de Flúor / Receptores de Hormônio Liberador da Corticotropina / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Marcação por Isótopo Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radioisótopos de Flúor / Receptores de Hormônio Liberador da Corticotropina / Compostos Radiofarmacêuticos / Tomografia por Emissão de Pósitrons / Marcação por Isótopo Idioma: En Ano de publicação: 2015 Tipo de documento: Article