Tumorigenesis: it takes a village.
Nat Rev Cancer
; 15(8): 473-83, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-26156638
ABSTRACT
Although it is widely accepted that most cancers exhibit some degree of intratumour heterogeneity, we are far from understanding the dynamics that operate among subpopulations within tumours. There is growing evidence that cancer cells behave as communities, and increasing attention is now being directed towards the cooperative behaviour of subclones that can influence disease progression. As expected, these interactions can add a greater layer of complexity to therapeutic interventions in heterogeneous tumours, often leading to a poor prognosis. In this Review, we highlight studies that demonstrate such interactions in cancer and postulate ways to overcome them with better-designed therapeutic strategies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Carcinogênese
/
Neoplasias
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos