Association of neuropsychiatric symptoms and sub-syndromes with cognitive impairment in community-dwelling Asian elderly.
Int Psychogeriatr
; 27(11): 1839-47, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-26201550
ABSTRACT
OBJECTIVES:
To investigate the presence of neuropsychiatric symptoms (NPS) and sub-syndromes in elderly community-dwelling Asians with varying severity of cognitive impairment.METHODS:
Chinese and Malay participants (n = 613) from the Epidemiology of Dementia in Singapore (EDIS) Study aged ≥ 60 years underwent clinical examination, neuropsychological testing, and NPS assessment using the Neuropsychiatric Inventory (NPI). Diagnosis of no cognitive impairment (NCI), cognitive impairment-no dementia (CIND), including CIND-mild and CIND-moderate, and dementia were made using established criteria.RESULTS:
A significant increase in the numbers of NPS was observed accompanying with increasing severity of cognitive impairment (p < 0.001). Compared to those with NCI/CIND-mild, participants with CIND-moderate [Odds ratio (OR) 4.2, 95% confidence interval (CI) 1.8-10.0] or dementia [OR 9.2, 95% CI 2.3-36.0] were more likely to have two or more neuropsychiatric sub-syndromes. Participants with CIND-moderate were more likely to have hyperactivity [OR 2.0, 95% CI 1.0-3.8] and apathy [OR 2.9, 95% CI 1.0-8.4] sub-syndromes, whereas patients with dementia were more likely to have psychosis [OR 6.9, 95% CI 2.4-20.1], affective (OR 8.7, 95% CI 1.8-42.9), and hyperactivity (OR 5.4, 95% CI 1.8-16.1). Furthermore, executive dysfunction and visual memory impairment were associated with the presence of three neuropsychiatric sub-syndromes; whist language and visuomotor speed impairment were related to the presence of two sub-syndromes. By contrast, impairment in attention, verbal memory, and visuoconstruction were not associated with any of the sub-syndromes.CONCLUSIONS:
The presence of NPS and sub-syndromes increase with increasing severities of cognitive impairment, and different neuropsychiatric syndromes are associated with specific impairment on cognitive domains in community-dwelling Asian elderly.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Cognitivos
/
Demência
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Singapura