Low-dose ara-C therapy for acute myelogenous leukemia in elderly patients.
Leukemia
; 3(1): 23-8, 1989 Jan.
Article
em En
| MEDLINE
| ID: mdl-2642574
ABSTRACT
Forty-four evaluable patients with untreated acute myelogenous leukemia received twice-daily subcutaneous injections of low-dose ara-C (10 mg/m2) for less than or equal to 42 days. The median age was 72 years (range 53-87); 42 of 44 patients were greater than or equal to age 60. Ten patients (23%) had complete responses with a median duration of 9.9 months. Median survival was 3 months (range 0.6-31.2+) for all patients, and 19.5 (range 7.9-31.2+) for patients who attained complete responses. Cytoreduction occurred slowly with low-dose ara-C and five of ten patients who achieved complete remission did not develop marrow aplasia. Toxicity was predominantly related to infections associated with granulocytopenia. Nonhematologic toxicity was limited. Low-dose ara-C as used in this trial results in a complete response rate and a duration of response similar to those achieved with other treatments in elderly patients, but with reduced toxicity.
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Leucemia Mieloide Aguda
/
Citarabina
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article