Discovery of an ultra-short linear antibacterial tetrapeptide with anti-MRSA activity from a structure-activity relationship study.

Lau, Qiu Ying; Ng, Fui Mee; Cheong, Jin Wei Darryl; Yap, Yi Yong Alvin; Tan, Yoke Yan Fion; Jureen, Roland; Hill, Jeffrey; Chia, Cheng San Brian

Lau, Qiu Ying; Ng, Fui Mee; Cheong, Jin Wei Darryl; Yap, Yi Yong Alvin; Tan, Yoke Yan Fion; Jureen, Roland; Hill, Jeffrey; Chia, Cheng San Brian.

Afiliação

Lau QY; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01 138669, Singapore.
Ng FM; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01 138669, Singapore.
Cheong JW; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01 138669, Singapore.
Yap YY; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01 138669, Singapore.
Tan YY; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01 138669, Singapore.
Jureen R; Department of Laboratory Medicine, National University Hospital, 5 Lower Kent Ridge Road 119074, Singapore.
Hill J; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01 138669, Singapore.
Chia CS; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01 138669, Singapore. Electronic address: cschia@etc.a-star.edu.sg.

Eur J Med Chem ; 105: 138-44, 2015 Nov 13.

Article em En | MEDLINE | ID: mdl-26489599

Assuntos

Antibacterianos/química; Antibacterianos/farmacologia; Descoberta de Drogas; Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos; Oligopeptídeos/química; Oligopeptídeos/farmacologia; Antibacterianos/síntese química; Relação Dose-Resposta a Droga; Eritrócitos/efeitos dos fármacos; Eritrócitos/metabolismo; Humanos; Conformação Molecular; Oligopeptídeos/síntese química; Relação Estrutura-Atividade

Palavras-chave

Antibacterial peptide; Antimicrobial peptide; MRSA; SSTI; Skin infection

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Staphylococcus aureus Resistente à Meticilina / Descoberta de Drogas / Antibacterianos Idioma: En Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Singapura

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