Natural supramolecular protein assemblies.
Chem Soc Rev
; 45(1): 24-39, 2016 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-26497225
ABSTRACT
Supramolecular protein assemblies are an emerging area within the chemical sciences, which combine the topological structures of the field of supramolecular chemistry and the state-of-the-art chemical biology approaches to unravel the formation and function of protein assemblies. Recent chemical and biological studies on natural multimeric protein structures, including fibers, rings, tubes, catenanes, knots, and cages, have shown that the quaternary structures of proteins are a prerequisite for their highly specific biological functions. In this review, we illustrate that a striking structural diversity of protein assemblies is present in nature. Furthermore, we describe structure-function relationship studies for selected classes of protein architectures, and we highlight the techniques that enable the characterisation of supramolecular protein structures.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Complexos Multiproteicos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Holanda