Molecular Dynamics of Multivalent Soluble Antigen Arrays Support a Two-Signal Co-delivery Mechanism in the Treatment of Experimental Autoimmune Encephalomyelitis.

Hartwell, Brittany L; Smalter Hall, Aaron; Swafford, David; Sullivan, Bradley P; Garza, Aaron; Sestak, Joshua O; Northrup, Laura; Berkland, Cory

Hartwell, Brittany L; Smalter Hall, Aaron; Swafford, David; Sullivan, Bradley P; Garza, Aaron; Sestak, Joshua O; Northrup, Laura; Berkland, Cory.

Afiliação

Hartwell BL; Therapeutic Particles and Biomaterials Technology Laboratory, University of Kansas , 2030 Becker Drive, Lawrence, Kansas 66047, United States.
Smalter Hall A; Molecular Graphics and Modeling Laboratory, University of Kansas , 2034 Becker Drive, Lawrence, Kansas 66047, United States.
Swafford D; Therapeutic Particles and Biomaterials Technology Laboratory, University of Kansas , 2030 Becker Drive, Lawrence, Kansas 66047, United States.
Sullivan BP; Therapeutic Particles and Biomaterials Technology Laboratory, University of Kansas , 2030 Becker Drive, Lawrence, Kansas 66047, United States.
Garza A; Department of Pharmaceutical Chemistry, University of Kansas , 2095 Constant Avenue, Lawrence, Kansas 66047, United States.
Northrup L; Therapeutic Particles and Biomaterials Technology Laboratory, University of Kansas , 2030 Becker Drive, Lawrence, Kansas 66047, United States.
Berkland C; Department of Pharmaceutical Chemistry, University of Kansas , 2095 Constant Avenue, Lawrence, Kansas 66047, United States.

Mol Pharm ; 13(2): 330-43, 2016 Feb 01.

Article em En | MEDLINE | ID: mdl-26636828

Assuntos

Autoantígenos/imunologia; Sistemas de Liberação de Medicamentos; Encefalomielite Autoimune Experimental/terapia; Tolerância Imunológica/imunologia; Nanoestruturas/química; Polímeros/química; Animais; Encefalomielite Autoimune Experimental/imunologia; Feminino; Imunoterapia; Camundongos; Simulação de Dinâmica Molecular; Análise Serial de Proteínas

Palavras-chave

antigen-specific immunotherapy; autoimmunity; co-delivery; molecular dynamics; nanomaterials

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Autoantígenos / Sistemas de Liberação de Medicamentos / Nanoestruturas / Encefalomielite Autoimune Experimental / Tolerância Imunológica Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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