Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins.

Chen, Chi-Jene; Ermler, Megan E; Tan, Gene S; Krammer, Florian; Palese, Peter; Hai, Rong

Chen, Chi-Jene; Ermler, Megan E; Tan, Gene S; Krammer, Florian; Palese, Peter; Hai, Rong.

Afiliação

Chen CJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ermler ME; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Tan GS; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA florian.krammer@mssm.edu ronghai@ucr.edu.
Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hai R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA florian.krammer@mssm.edu ronghai@ucr.edu.

J Virol ; 90(7): 3789-93, 2016 Jan 13.

Article em En | MEDLINE | ID: mdl-26764009

RESUMO

A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.

Assuntos

Glicoproteínas de Hemaglutininação de Vírus da Influenza/biossíntese; Vírus da Influenza A/genética; Proteínas Recombinantes/biossíntese; Linhagem Celular; Epitopos/genética; Expressão Gênica; Instabilidade Genômica; Glicoproteínas de Hemaglutininação de Vírus da Influenza/genética; Humanos; Vírus da Influenza A/crescimento & desenvolvimento; Vírus da Influenza A/fisiologia; Vacinas contra Influenza/genética; Testes de Neutralização; Proteínas Recombinantes/genética; Ensaio de Placa Viral; Replicação Viral

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Proteínas Recombinantes / Glicoproteínas de Hemaglutininação de Vírus da Influenza Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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