Prefrontal Parvalbumin Neurons in Control of Attention.
Cell
; 164(1-2): 208-218, 2016 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-26771492
ABSTRACT
While signatures of attention have been extensively studied in sensory systems, the neural sources and computations responsible for top-down control of attention are largely unknown. Using chronic recordings in mice, we found that fast-spiking parvalbumin (FS-PV) interneurons in medial prefrontal cortex (mPFC) uniformly show increased and sustained firing during goal-driven attentional processing, correlating to the level of attention. Elevated activity of FS-PV neurons on the timescale of seconds predicted successful execution of behavior. Successful allocation of attention was characterized by strong synchronization of FS-PV neurons, increased gamma oscillations, and phase locking of pyramidal firing. Phase-locked pyramidal neurons showed gamma-phase-dependent rate modulation during successful attentional processing. Optogenetic silencing of FS-PV neurons deteriorated attentional processing, while optogenetic synchronization of FS-PV neurons at gamma frequencies had pro-cognitive effects and improved goal-directed behavior. FS-PV neurons thus act as a functional unit coordinating the activity in the local mPFC circuit during goal-driven attentional processing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Atenção
/
Córtex Pré-Frontal
/
Neurônios
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Suécia