Re-examining the Nature and Function of Self-Reactive T cells.
Trends Immunol
; 37(2): 114-125, 2016 Feb.
Article
em En
| MEDLINE
| ID: mdl-26795134
ABSTRACT
Recent studies have leveraged MHC tetramer and TCR sequencing approaches towards a more precise characterization of the peripheral T cell repertoire, providing important insight into both the contribution of self-reactive T cells to the overall repertoire and their function. The peripheral T cell repertoire of healthy individuals contains a high frequency of diverse, self-reactive T cells. Furthermore, self-reactive T cells can perform essential beneficial physiological functions. We review these recent findings here, and discuss their implications to the current understanding of peripheral tolerance and the role of self-reactive T cells in autoimmune disease. We outline gaps in understanding, and argue that an important step forward is to revise the definition of self-reactive T cells to incorporate new concepts regarding the nature and physiological functions of different populations of T cells capable of recognizing self-antigens.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Linfócitos T
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Subpopulações de Linfócitos T
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Alemanha