'Pre-prosthetic use of poly(lactic-co-glycolic acid) membranes treated with oxygen plasma and TiO2 nanocomposite particles for guided bone regeneration processes'.
J Dent
; 47: 71-9, 2016 Apr.
Article
em En
| MEDLINE
| ID: mdl-26850906
ABSTRACT
OBJECTIVES:
Guided bone regeneration (GBR) processes are frequently necessary to achieve appropriate substrates before the restoration of edentulous areas. This study aimed to evaluate the bone regeneration reliability of a new poly-lactic-co-glycolic acid (PLGA) membrane after treatment with oxygen plasma (PO2) and titanium dioxide (TiO2) composite nanoparticles.METHODS:
Circumferential bone defects (diameter 10mm; depth 3mm) were created on the parietal bones of eight experimentation rabbits and were randomly covered with control membranes (Group 1 PLGA) or experimental membranes (Group 2 PLGA/PO2/TiO2). The animals were euthanized two months afterwards, and a morphologic study was then performed under microscope using ROI (region of interest) colour analysis. Percentage of new bone formation, length of mineralised bone formed in the grown defects, concentration of osteoclasts, and intensity of osteosynthetic activity were assessed. Comparisons among the groups and with the original bone tissue were made using the Kruskal-Wallis test. The level of significance was set in advance at a=0.05.RESULTS:
The experimental group recorded higher values for new bone formation, mineralised bone length, and osteoclast concentration; this group also registered the highest osteosynthetic activity. Bone layers in advanced formation stages and low proportions of immature tissue were observed in the study group.CONCLUSIONS:
The functionalised membranes showed the best efficacy for bone regeneration. CLINICALSIGNIFICANCE:
The addition of TiO2 nanoparticles onto PLGA/PO2 membranes for GBR processes may be a promising technique to restore bone dimensions and anatomic contours as a prerequisite to well-supported and natural-appearing prosthetic rehabilitations.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
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Ácido Poliglicólico
/
Titânio
/
Regeneração Óssea
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Ácido Láctico
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Regeneração Tecidual Guiada
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Nanocompostos
/
Gases em Plasma
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Membranas Artificiais
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Espanha