Evidence for the recruitment of autophagic vesicles in human brain after stroke.
Neurochem Int
; 96: 62-8, 2016 06.
Article
em En
| MEDLINE
| ID: mdl-26930584
ABSTRACT
Autophagy is a homeostatic process for recycling proteins and organelles that is increasingly being proposed as a therapeutic target for acute and chronic neurodegenerative diseases, including stroke. Confirmation that autophagy is present in the human brain after stroke is imperative before prospective therapies can begin the translational process into clinical trials. Our current study using human post-mortem tissue observed an increase in staining in microtubule-associated protein 1 light chain 3 (LC3), sequestosome 1 (SQSTM1; also known as p62) and the increased appearance of autophagic vesicles after stroke. These data confirm that alterations in autophagy take place in the human brain after stroke and suggest that targeting autophagic processes after stroke may have clinical significance.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Encéfalo
/
Acidente Vascular Cerebral
/
Proteína Sequestossoma-1
/
Proteína Beclina-1
/
Proteínas Associadas aos Microtúbulos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Austrália