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Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.
Borthwick, Jennifer A; Ancellin, Nicolas; Bertrand, Sophie M; Bingham, Ryan P; Carter, Paul S; Chung, Chun-wa; Churcher, Ian; Dodic, Nerina; Fournier, Charlène; Francis, Peter L; Hobbs, Andrew; Jamieson, Craig; Pickett, Stephen D; Smith, Sarah E; Somers, Donald O'N; Spitzfaden, Claus; Suckling, Colin J; Young, Robert J.
Afiliação
  • Borthwick JA; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Ancellin N; Department of Pure and Applied Chemistry, University of Strathclyde , 295 Cathedral Street, Glasgow, G1 1XL, U.K.
  • Bertrand SM; Les Ulis, Centre de Recherche, GlaxoSmithKline R&D , 25,27 Avenue du Québec, 91140 Villebon sur Yvette, France.
  • Bingham RP; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Carter PS; Department of Pure and Applied Chemistry, University of Strathclyde , 295 Cathedral Street, Glasgow, G1 1XL, U.K.
  • Chung CW; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Churcher I; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Dodic N; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Fournier C; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Francis PL; Les Ulis, Centre de Recherche, GlaxoSmithKline R&D , 25,27 Avenue du Québec, 91140 Villebon sur Yvette, France.
  • Hobbs A; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Jamieson C; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Pickett SD; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Smith SE; Department of Pure and Applied Chemistry, University of Strathclyde , 295 Cathedral Street, Glasgow, G1 1XL, U.K.
  • Somers DO; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Spitzfaden C; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Suckling CJ; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
  • Young RJ; Medicines Research Centre, GlaxoSmithKline R&D , Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, U.K.
J Med Chem ; 59(6): 2452-67, 2016 Mar 24.
Article em En | MEDLINE | ID: mdl-26938474
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transaminases / Mitocôndrias Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transaminases / Mitocôndrias Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Reino Unido