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Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Walsh, Shawn P; Shahripour, Aurash; Tang, Haifeng; de Jesus, Reynalda K; Teumelsan, Nardos; Zhu, Yuping; Frie, Jessica; Priest, Birgit T; Swensen, Andrew M; Alonso-Galicia, Magdalena; Felix, John P; Brochu, Richard M; Bailey, Timothy; Thomas-Fowlkes, Brande; Zhou, Xiaoyan; Pai, Lee-Yuh; Hampton, Caryn; Hernandez, Melba; Owens, Karen; Ehrhart, Juliann; Roy, Sophie; Kaczorowski, Gregory J; Yang, Lihu; Garcia, Maria L; Pasternak, Alexander.
Afiliação
  • Walsh SP; Discovery Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, United States. Electronic address: shawn_walsh@merck.com.
  • Shahripour A; Discovery Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Tang H; Discovery Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • de Jesus RK; Discovery Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Teumelsan N; Discovery Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Zhu Y; Discovery Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Frie J; Discovery Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Priest BT; Department of Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Swensen AM; Department of Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Alonso-Galicia M; Department of Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Felix JP; Department of Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Brochu RM; Department of Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Bailey T; Department of Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Thomas-Fowlkes B; Department of Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Zhou X; Department of Cardiometabolic Diseases, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Pai LY; Department of Cardiometabolic Diseases, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Hampton C; Department of Cardiometabolic Diseases, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Hernandez M; Department of Cardiometabolic Diseases, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Owens K; Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Ehrhart J; Department of Safety Assessment and Lab Animal Research, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Roy S; Department of Cardiometabolic Diseases, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Kaczorowski GJ; Department of Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Yang L; Discovery Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Garcia ML; Department of Pharmacology, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
  • Pasternak A; Discovery Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, United States.
Bioorg Med Chem Lett ; 26(9): 2339-43, 2016 May 01.
Article em En | MEDLINE | ID: mdl-27017115
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Canal de Potássio ERG1 / Compostos Heterocíclicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Canal de Potássio ERG1 / Compostos Heterocíclicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article