Rifampin phosphotransferase is an unusual antibiotic resistance kinase.

Stogios, Peter J; Cox, Georgina; Spanogiannopoulos, Peter; Pillon, Monica C; Waglechner, Nicholas; Skarina, Tatiana; Koteva, Kalinka; Guarné, Alba; Savchenko, Alexei; Wright, Gerard D

Stogios, Peter J; Cox, Georgina; Spanogiannopoulos, Peter; Pillon, Monica C; Waglechner, Nicholas; Skarina, Tatiana; Koteva, Kalinka; Guarné, Alba; Savchenko, Alexei; Wright, Gerard D.

Afiliação

Stogios PJ; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada M5G 1L6.
Cox G; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1.
Spanogiannopoulos P; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1.
Pillon MC; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1.
Waglechner N; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1.
Skarina T; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1.
Koteva K; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1.
Guarné A; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1.
Savchenko A; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada M5G 1L6.
Wright GD; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, Ontario, Canada L8S 4K1.

Nat Commun ; 7: 11343, 2016 Apr 22.

Article em En | MEDLINE | ID: mdl-27103605

Assuntos

Antibacterianos/metabolismo; Proteínas de Bactérias/química; Listeria monocytogenes/enzimologia; Fosfotransferases/química; Rifampina/metabolismo; Trifosfato de Adenosina/química; Trifosfato de Adenosina/metabolismo; Sequência de Aminoácidos; Antibacterianos/farmacologia; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Sítios de Ligação; Biotransformação; Cristalografia por Raios X; Farmacorresistência Bacteriana; Escherichia coli/genética; Escherichia coli/metabolismo; Expressão Gênica; Listeria monocytogenes/classificação; Listeria monocytogenes/efeitos dos fármacos; Listeria monocytogenes/genética; Modelos Moleculares; Dados de Sequência Molecular; Fosfotransferases/genética; Fosfotransferases/metabolismo; Filogenia; Ligação Proteica; Estrutura Secundária de Proteína; Estrutura Terciária de Proteína; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Rifampina/farmacologia; Alinhamento de Sequência

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfotransferases / Rifampina / Proteínas de Bactérias / Listeria monocytogenes / Antibacterianos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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