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RIG-I ligand enhances the immunogenicity of recombinant H7HA protein.
Cao, Weiping; Liepkalns, Justine S; Kamal, Ram P; Reber, Adrian J; Kim, Jin Hyang; Hofstetter, Amelia R; Amoah, Samuel; Stevens, James; Ranjan, Priya; Gangappa, Shivaprakash; York, Ian A; Sambhara, Suryaprakash.
Afiliação
  • Cao W; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA. Electronic address: wcao@cdc.gov.
  • Liepkalns JS; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Kamal RP; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA; Battelle Memorial Institute, Atlanta, GA, USA.
  • Reber AJ; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Kim JH; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Hofstetter AR; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.
  • Amoah S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA; Battelle Memorial Institute, Atlanta, GA, USA.
  • Stevens J; Virus, Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Ranjan P; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Gangappa S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • York IA; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
  • Sambhara S; Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.
Cell Immunol ; 304-305: 55-8, 2016.
Article em En | MEDLINE | ID: mdl-27106062
ABSTRACT
Avian H7N9 influenza virus infection with fatal outcomes continues to pose a pandemic threat and highly immunogenic vaccines are urgently needed. In this report we show that baculovirus-derived recombinant H7 hemagglutinin protein, when delivered with RIG-I ligand, induced enhanced antibody and T cell responses and conferred protection against lethal challenge with a homologous H7N9 virus. These findings indicate the potential utility of RIG-I ligands as vaccine adjuvants to increase the immunogenicity of recombinant H7 hemagglutinin.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Linfócitos T / Infecções por Orthomyxoviridae / Glicoproteínas de Hemaglutininação de Vírus da Influenza / Influenza Humana / Subtipo H7N9 do Vírus da Influenza A / Proteína DEAD-box 58 Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra Influenza / Linfócitos T / Infecções por Orthomyxoviridae / Glicoproteínas de Hemaglutininação de Vírus da Influenza / Influenza Humana / Subtipo H7N9 do Vírus da Influenza A / Proteína DEAD-box 58 Idioma: En Ano de publicação: 2016 Tipo de documento: Article