Synergistic effects of c-Jun and SP1 in the promotion of TGFß1-mediated diabetic nephropathy progression.

Gao, Pan; Wei, Yingze; Zhang, Zhigang; Zeng, Wenjiao; Sun, Daming; Liu, Danyang; Hou, Bo; Zhang, Congying; Zhang, Nong; Li, Hui; Li, Liliang

Gao, Pan; Wei, Yingze; Zhang, Zhigang; Zeng, Wenjiao; Sun, Daming; Liu, Danyang; Hou, Bo; Zhang, Congying; Zhang, Nong; Li, Hui; Li, Liliang.

Afiliação

Gao P; Department of Pathology, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai 200032, China; Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.
Wei Y; Department of Pathology, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai 200032, China.
Zhang Z; Department of Pathology, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai 200032, China.
Zeng W; Department of Pathology, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai 200032, China.
Sun D; Forensic Science Center, East China University of Political Science and Law, 112 Huayang Road, Changning District, Shanghai 200042, China.
Liu D; Department of Pathology, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai 200032, China.
Hou B; Department of Pathology, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai 200032, China.
Zhang C; Department of Pathology, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai 200032, China.
Zhang N; Department of Pathology, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai 200032, China.
Li H; Department of Pathology, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai 200032, China. Electronic address: huili78@fudan.edu.cn.
Li L; Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, 138 Yixueyuan Road, Xuhui District, Shanghai 200032, China. Electronic address: 11111010016@fudan.edu.cn.

Exp Mol Pathol ; 100(3): 441-50, 2016 06.

Article em En | MEDLINE | ID: mdl-27112839

Assuntos

Nefropatias Diabéticas/metabolismo; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; Proteínas Proto-Oncogênicas c-jun/metabolismo; Fator de Transcrição Sp1/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Adulto; Idoso; Animais; Antracenos/farmacologia; Western Blotting; Linhagem Celular; Nefropatias Diabéticas/genética; Nefropatias Diabéticas/patologia; Progressão da Doença; Feminino; Glucose/farmacologia; Humanos; Proteínas Quinases JNK Ativadas por Mitógeno/antagonistas & inibidores; Proteínas Quinases JNK Ativadas por Mitógeno/genética; Masculino; Células Mesangiais/efeitos dos fármacos; Células Mesangiais/metabolismo; Camundongos Endogâmicos C57BL; Microscopia de Fluorescência; Pessoa de Meia-Idade; Mutação; Fosforilação; Regiões Promotoras Genéticas/genética; Proteínas Proto-Oncogênicas c-jun/antagonistas & inibidores; Proteínas Proto-Oncogênicas c-jun/genética; Interferência de RNA; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Fator de Transcrição Sp1/genética; Fator de Crescimento Transformador beta1/genética

Palavras-chave

Diabetic nephropathy; Phosphorylation; SP1; Synergy; TGFß1; c-Jun

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Transcrição Sp1 / Proteínas Proto-Oncogênicas c-jun / Proteínas Quinases JNK Ativadas por Mitógeno / Nefropatias Diabéticas / Fator de Crescimento Transformador beta1 Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Estados Unidos

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