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CRISPR-Mediated Drug-Target Validation Reveals Selective Pharmacological Inhibition of the RNA Helicase, eIF4A.
Chu, Jennifer; Galicia-Vázquez, Gabriela; Cencic, Regina; Mills, John R; Katigbak, Alexandra; Porco, John A; Pelletier, Jerry.
Afiliação
  • Chu J; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
  • Galicia-Vázquez G; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
  • Cencic R; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
  • Mills JR; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
  • Katigbak A; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada.
  • Porco JA; Department of Chemistry, Center for Molecular Discovery (BU-CMD), Boston University, 590 Commonwealth Avenue, Boston, MA 02215, USA.
  • Pelletier J; Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada; The Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, QC H3G 1Y6, Canada; Department of Oncology, McGill University, Montreal, QC H3G 1Y6, Canada. Electronic address: jerry.pelletier@mcgill.ca
Cell Rep ; 15(11): 2340-7, 2016 06 14.
Article em En | MEDLINE | ID: mdl-27239032
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofuranos / Sistemas de Liberação de Medicamentos / Fator de Iniciação 4A em Eucariotos / Sistemas CRISPR-Cas Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofuranos / Sistemas de Liberação de Medicamentos / Fator de Iniciação 4A em Eucariotos / Sistemas CRISPR-Cas Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Canadá