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Access to C4-Functionalized Quinolines via Copper-Catalyzed Tandem Annulation of Alkynyl Imines with Diazo Compounds.
Zhu, Ruifeng; Cheng, Guolin; Jia, Chunqi; Xue, Lulu; Cui, Xiuling.
Afiliação
  • Zhu R; Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education , Xiamen 361021, China.
  • Cheng G; Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education , Xiamen 361021, China.
  • Jia C; Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education , Xiamen 361021, China.
  • Xue L; Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education , Xiamen 361021, China.
  • Cui X; Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University and Engineering Research Center of Molecular Medicine, Ministry of Education , Xiamen 361021, China.
J Org Chem ; 81(17): 7539-44, 2016 09 02.
Article em En | MEDLINE | ID: mdl-27405000
ABSTRACT
An efficient synthesis of C4-functionalized quinolines through copper-catalyzed tandem annulation of alkynyl imines with diazo compounds is described. This transformation involves an in situ formation of allene and intramolecular electrocyclization, which features high efficiency, mild reaction conditions, easy operation, and broad functional-group tolerance. A wide variety of C4-functionalized quinolines were provided in up to 92% yield for 33 examples.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China