Family History and Risk of Recurrent Stroke.
Stroke
; 47(8): 1990-6, 2016 08.
Article
em En
| MEDLINE
| ID: mdl-27406105
ABSTRACT
BACKGROUND AND PURPOSE:
The association between family history of stroke and stroke recurrence remains unclear.METHODS:
Using a web-based multicenter stroke registry database, information on history of stroke in first-degree relatives was collected prospectively for acute ischemic stroke patients who were hospitalized within 7 days of onset. The collected information was categorized as follows type of the affected relative(s) with stroke (paternal, maternal, sibling, or 2 or more) and age of the relative's stroke onset (<50, 50-59, 60-69, and ≥70 years). Stroke recurrence was captured prospectively using a predetermined protocol. Subgroup analyses were performed according to the patient's age at the index stroke.RESULTS:
Among 7642 patients, 937 (12.3%) had a history of stroke in their first-degree relatives and 475 (6.2% 201 within and 274 after 3 weeks from index stroke) experienced stroke recurrence (median follow-up, 365 days). In multivariable Cox proportional hazard models, overall family history was not associated with stroke recurrence (hazard ratio, 1.08; 95% confidence interval, 0.81-1.43). However, the details of their family histories, including relative's age at stroke onset (<50 years hazard ratio, 2.14; 95% confidence interval, 1.004-4.54) and stroke history in a sibling (hazard ratio, 1.67; 95% confidence interval, 1.09-2.58), were independently associated with stroke recurrence after adjusting for potential confounders. The associations appeared to be stronger in young adults with stroke (age, <55 years) than in older stroke patients.CONCLUSIONS:
This study suggests that elevated risks of recurrent stroke are associated with having relatives with early-onset stroke and siblings with stroke histories, implying that additional precautions may be needed in such populations.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Família
/
Isquemia Encefálica
/
Acidente Vascular Cerebral
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article