Structure Change from ß-Strand and Turn to α-Helix in Histone H2A-H2B Induced by DNA Damage Response.
Biophys J
; 111(1): 69-78, 2016 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-27410735
ABSTRACT
Using synchrotron radiation-based circular dichroism spectroscopy, we found that the DNA damage response induces an increase of α-helix structure and a decrease of ß-strand and turn structures in histone H2A-H2B extracted from x-irradiated human HeLa cells. The structural alterations correspond to the assumption that an average of eight amino acid residues form new α-helix structures at 310 K. We propose the structural transition from ß-strand and turn structures to an α-helix structure in H2A-H2B as a novel, to our knowledge, process involved in the DNA damage response.
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1
Base de dados:
MEDLINE
Assunto principal:
Dano ao DNA
/
Histonas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article