1&#945;,2&#945;-Epoxy-3ß-hydroxy oleanolic acid derivatives regulation of the metabolism, haemolysis and ß-lactamase gene expression in vitro and their structure-microbicidal activity relationship.

Liang, Zheng-Ming; Wang, Xing-Hui; Huang, Li-Rong; Li, Qi-Ji; Guan, Tian-Qi; Hao, Xiao-Jiang; Luo, Heng; Yang, Xiao-Sheng

1α,2α-Epoxy-3ß-hydroxy oleanolic acid derivatives regulation of the metabolism, haemolysis and ß-lactamase gene expression in vitro and their structure-microbicidal activity relationship.

Liang, Zheng-Ming; Wang, Xing-Hui; Huang, Li-Rong; Li, Qi-Ji; Guan, Tian-Qi; Hao, Xiao-Jiang; Luo, Heng; Yang, Xiao-Sheng.

Afiliação

Liang ZM; Guizhou University, Guiyang, Guizhou, China; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, 202 South Sha-chong Road, Guiyang, Guizhou, China.
Wang XH; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, 202 South Sha-chong Road, Guiyang, Guizhou, China.
Huang LR; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, 202 South Sha-chong Road, Guiyang, Guizhou, China.
Li QJ; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, 202 South Sha-chong Road, Guiyang, Guizhou, China.
Guan TQ; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, 202 South Sha-chong Road, Guiyang, Guizhou, China.
Hao XJ; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, 202 South Sha-chong Road, Guiyang, Guizhou, China.
Luo H; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, 202 South Sha-chong Road, Guiyang, Guizhou, China. Electronic address: luoheng71050@aliyun.com.
Yang XS; Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, 202 South Sha-chong Road, Guiyang, Guizhou, China. Electronic address: gzcnp@sina.com.

Bioorg Med Chem Lett ; 26(16): 3870-5, 2016 08 15.

Article em En | MEDLINE | ID: mdl-27436581

Assuntos

Antibacterianos/química; Ácido Oleanólico/análogos & derivados; beta-Lactamases/metabolismo; Acinetobacter/efeitos dos fármacos; Acinetobacter/genética; Acinetobacter/metabolismo; Antibacterianos/síntese química; Antibacterianos/farmacologia; Bacillus subtilis/efeitos dos fármacos; Bacillus subtilis/genética; Bacillus subtilis/metabolismo; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Escherichia coli/efeitos dos fármacos; Escherichia coli/genética; Escherichia coli/metabolismo; Expressão Gênica/efeitos dos fármacos; Hemólise/efeitos dos fármacos; Klebsiella pneumoniae/efeitos dos fármacos; Klebsiella pneumoniae/genética; Klebsiella pneumoniae/metabolismo; Testes de Sensibilidade Microbiana; Ácido Oleanólico/síntese química; Ácido Oleanólico/farmacologia; Reação em Cadeia da Polimerase em Tempo Real; Relação Estrutura-Atividade; Triterpenos/química; beta-Lactamases/genética

Palavras-chave

1α,2α-Epoxy-3ß-hydroxyl oleanolic acid; Antibacterial activity; Genes expression; Synthesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Oleanólico / Beta-Lactamases / Antibacterianos Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China

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