Differences in contents of organochlorine impurities do not influence responses to patch testing with Majantol®.
Contact Dermatitis
; 76(1): 11-18, 2017 Jan.
Article
em En
| MEDLINE
| ID: mdl-27555089
ABSTRACT
BACKGROUND:
Majantol® [2,2-dimethyl-3-(3-methylphenyl)propan-1-ol; CAS no. 103694-68-4] has been identified as a contact allergen in humans, despite negative animal tests. Hence impurities, specifically organochlorines, in Majantol® might have been the reason for positive patch test reactions in the past.OBJECTIVES:
To assess elicitation via patch testing with a standard market-quality version of Majantol® ('normal') with a normal content of organochlorine impurities, as compared with an ultra-purified version of Majantol® ('pure'), without detectable organochlorine impurities.METHODS:
Between 1 October 2013 and 31 December 2014, two different Majantol® patch test preparations of the above-mentioned quality were tested 5% pet. in parallel in the 'monitor series', that is, together with the baseline series, in 8005 consecutive patients from 33 departments of dermatology of the Information Network of Departments of Dermatology (IVDK).RESULTS:
Fifty-three of 7740 [0.69% (95%CI 0.51-0.87)] patch tested patients reacted to at least one Majantol® preparation. The majority (n = 32) (60.4%) reacted to both preparations, 13 (24.5%) reacted to the 'normal' version only, and 8 (15.1%) reacted to the 'pure' version only. There was good concordance between results [Cohen's kappa 0.75 (95%CI 0.65-0.85)], and there was no significant difference in frequency or intensity between the two preparations. More doubtful or irritant reactions than positive reactions were observed, and> 80% of all positive reactions were weak positive.CONCLUSION:
Organochlorine impurities are very probably not the cause of allergic reactions to Majantol®.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Tolueno
/
Alérgenos
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Dermatite Alérgica de Contato
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Hidrocarbonetos Clorados
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Alemanha