In-Vivo Proton Magnetic Resonance Spectroscopy of 2-Hydroxyglutarate in Isocitrate Dehydrogenase-Mutated Gliomas: A Technical Review for Neuroradiologists.
Korean J Radiol
; 17(5): 620-32, 2016.
Article
em En
| MEDLINE
| ID: mdl-27587950
ABSTRACT
The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently. However, due to severe spectral overlap with background signals, quantification of 2HG can be very challenging. In this technical review for neuroradiologists, first, the biochemistry of 2HG and its significance in the diagnosis of IDH-MT gliomas are summarized. Secondly, various 1H-MRS methods used in the previous studies are outlined. Finally, wereview previous in vivo studies, and discuss the current status of 1H-MRS in the diagnosis of IDH-MT gliomas.
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MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Biomarcadores Tumorais
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Espectroscopia de Prótons por Ressonância Magnética
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Glioma
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Glutaratos
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Isocitrato Desidrogenase
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article