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Small-molecule factor D inhibitors targeting the alternative complement pathway.
Maibaum, Jürgen; Liao, Sha-Mei; Vulpetti, Anna; Ostermann, Nils; Randl, Stefan; Rüdisser, Simon; Lorthiois, Edwige; Erbel, Paul; Kinzel, Bernd; Kolb, Fabrice A; Barbieri, Samuel; Wagner, Julia; Durand, Corinne; Fettis, Kamal; Dussauge, Solene; Hughes, Nicola; Delgado, Omar; Hommel, Ulrich; Gould, Ty; Mac Sweeney, Aengus; Gerhartz, Bernd; Cumin, Frederic; Flohr, Stefanie; Schubart, Anna; Jaffee, Bruce; Harrison, Richard; Risitano, Antonio Maria; Eder, Jörg; Anderson, Karen.
Afiliação
  • Maibaum J; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Liao SM; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
  • Vulpetti A; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Ostermann N; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Randl S; Evonik Japan Co., Shinjuku-ku, Tokyo, Japan.
  • Rüdisser S; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Lorthiois E; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Erbel P; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Kinzel B; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Kolb FA; Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.
  • Barbieri S; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Wagner J; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Durand C; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Fettis K; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Dussauge S; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Hughes N; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Delgado O; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
  • Hommel U; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Gould T; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
  • Mac Sweeney A; Drug Discovery Department, Actelion Pharmaceuticals Ltd., Allschwil, Switzerland.
  • Gerhartz B; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Cumin F; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Flohr S; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Schubart A; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Jaffee B; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
  • Harrison R; Institute of Infection and Immunity, School of Medicine, Cardiff University, Henry Wellcome Building, Heath Park, Cardiff, UK.
  • Risitano AM; University of Naples, Department of Clinical Medicine and Surgery, Division of Hematology, Naples, Italy.
  • Eder J; Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, Basel, Switzerland.
  • Anderson K; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.
Nat Chem Biol ; 12(12): 1105-1110, 2016 Dec.
Article em En | MEDLINE | ID: mdl-27775713
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator D do Complemento / Via Alternativa do Complemento / Inibidores Enzimáticos / Bibliotecas de Moléculas Pequenas Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator D do Complemento / Via Alternativa do Complemento / Inibidores Enzimáticos / Bibliotecas de Moléculas Pequenas Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Suíça