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High Hepsin expression predicts poor prognosis in Gastric Cancer.
Zhang, Mingming; Zhao, Junjie; Tang, Wenyi; Wang, Yanru; Peng, Peike; Li, Lili; Song, Shushu; Wu, Hao; Li, Can; Yang, Caiting; Wang, Xuefei; Zhang, Chunyi; Gu, Jianxin.
Afiliação
  • Zhang M; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Zhao J; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  • Tang W; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Wang Y; Department of Anatomy and Histology &Embryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Peng P; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Li L; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Song S; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Wu H; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Li C; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Yang C; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Wang X; Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
  • Zhang C; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Gu J; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Sci Rep ; 6: 36902, 2016 11 14.
Article em En | MEDLINE | ID: mdl-27841306
ABSTRACT
Hepsin, a membrane-associated serine protease, is frequently upregulated in epithelial cancers and involved in cancer progression. Our study aims to describe the expression pattern and evaluate the clinical implication of hepsin in gastric cancer patients. The mRNA expression of hepsin was analyzed in 50 gastric cancer and matched non-tumor tissues, which was downregulated in 78% (39/50) of gastric cancer. By searching and analyzing four independent datasets from Oncomine, we obtained the similar results. Furthermore, we evaluated the hepsin expression by IHC in tissue microarray (TMA) containing 220 Gastric Cancer specimens. More importantly, Kaplan-Meier survival and Cox regression analyses were taken to access the prognosis of gastric cancer and predicted that hepsin protein expression was one of the significant and independent prognostic factors for overall survival of Gastric Cancer.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Serina Endopeptidases / Regulação para Cima Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Serina Endopeptidases / Regulação para Cima Idioma: En Ano de publicação: 2016 Tipo de documento: Article País de afiliação: China