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The Zebrafish Model Organism Database: new support for human disease models, mutation details, gene expression phenotypes and searching.
Howe, Douglas G; Bradford, Yvonne M; Eagle, Anne; Fashena, David; Frazer, Ken; Kalita, Patrick; Mani, Prita; Martin, Ryan; Moxon, Sierra Taylor; Paddock, Holly; Pich, Christian; Ramachandran, Sridhar; Ruzicka, Leyla; Schaper, Kevin; Shao, Xiang; Singer, Amy; Toro, Sabrina; Van Slyke, Ceri; Westerfield, Monte.
Afiliação
  • Howe DG; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA dhowe@zfin.org.
  • Bradford YM; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Eagle A; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Fashena D; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Frazer K; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Kalita P; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Mani P; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Martin R; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Moxon ST; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Paddock H; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Pich C; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Ramachandran S; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Ruzicka L; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Schaper K; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Shao X; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Singer A; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Toro S; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Van Slyke C; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
  • Westerfield M; The Institute of Neuroscience, University of Oregon, Eugene, OR 97403-1254, USA.
Nucleic Acids Res ; 45(D1): D758-D768, 2017 01 04.
Article em En | MEDLINE | ID: mdl-27899582
The Zebrafish Model Organism Database (ZFIN; http://zfin.org) is the central resource for zebrafish (Danio rerio) genetic, genomic, phenotypic and developmental data. ZFIN curators provide expert manual curation and integration of comprehensive data involving zebrafish genes, mutants, transgenic constructs and lines, phenotypes, genotypes, gene expressions, morpholinos, TALENs, CRISPRs, antibodies, anatomical structures, models of human disease and publications. We integrate curated, directly submitted, and collaboratively generated data, making these available to zebrafish research community. Among the vertebrate model organisms, zebrafish are superbly suited for rapid generation of sequence-targeted mutant lines, characterization of phenotypes including gene expression patterns, and generation of human disease models. The recent rapid adoption of zebrafish as human disease models is making management of these data particularly important to both the research and clinical communities. Here, we describe recent enhancements to ZFIN including use of the zebrafish experimental conditions ontology, 'Fish' records in the ZFIN database, support for gene expression phenotypes, models of human disease, mutation details at the DNA, RNA and protein levels, and updates to the ZFIN single box search.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Genômica / Bases de Dados Genéticas / Estudos de Associação Genética / Ferramenta de Busca Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Genômica / Bases de Dados Genéticas / Estudos de Associação Genética / Ferramenta de Busca Idioma: En Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Estados Unidos