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Circulating omentin-1 levels in women with polycystic ovary syndrome: a meta-analysis.
Tang, Yun-Liang; Yu, Jiao; Zeng, Zhen-Guo; Liu, Ying; Liu, Jian-Ying; Xu, Ji-Xiong.
Afiliação
  • Tang YL; a Department of Endocrinology and Metabolism and.
  • Yu J; a Department of Endocrinology and Metabolism and.
  • Zeng ZG; b Department of Intensive Care Unit , First Affiliated Hospital of Nanchang University , Nanchang , Jiangxi , PR China.
  • Liu Y; a Department of Endocrinology and Metabolism and.
  • Liu JY; a Department of Endocrinology and Metabolism and.
  • Xu JX; a Department of Endocrinology and Metabolism and.
Gynecol Endocrinol ; 33(3): 244-249, 2017 Mar.
Article em En | MEDLINE | ID: mdl-27908216
ABSTRACT
To investigate the association between circulating omentin-1 levels and polycystic ovary syndrome (PCOS) in women, a meta-analysis was performed. A systematic literature search using PubMed, Embase and Web of Science was carried out. Ten articles with 13 studies were included in this meta-analysis, which included a total of 1264 subjects (733 patients with PCOS and 531 controls). The pooled standard mean difference (SMD) and 95% confidence interval (CI) were used to estimate the association between omentin-1 levels and PCOS. Circulating omentin-1 levels were lower in PCOS with an SMD (95% CI) of -0.67 (-0.91, -0.43) and p = 0.000 (random-effects). However, significant heterogeneity was detected across studies (I2=73.6% and p = 0.000). The subgroup analysis suggested that omentin-1 levels in PCOS patients were associated with HOMA-IR ratio. Meta-regression analysis indicated region was the main source of heterogeneity (p = 0.048). The results of this meta-analysis suggested that circulating omentin-1 levels are significantly lower in women with PCOS compared with controls, which indicated that omentin-1 may play a role in the pathologic processes of PCOS.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Resistência à Insulina / Regulação para Baixo / Citocinas / Lectinas Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Resistência à Insulina / Regulação para Baixo / Citocinas / Lectinas Idioma: En Ano de publicação: 2017 Tipo de documento: Article