A Janus Chelator Enables Biochemically Responsive MRI Contrast with Exceptional Dynamic Range.
J Am Chem Soc
; 138(49): 15861-15864, 2016 12 14.
Article
em En
| MEDLINE
| ID: mdl-27960350
ABSTRACT
We introduce a new biochemically responsive Mn-based MRI contrast agent that provides a 9-fold change in relaxivity via switching between the Mn3+ and Mn2+ oxidation states. Interchange between oxidation states is promoted by a "Janus" ligand that isomerizes between binding modes that favor Mn3+ or Mn2+. It is the only ligand that supports stable complexes of Mn3+ and Mn2+ in biological milieu. Rapid interconversion between oxidation states is mediated by peroxidase activity (oxidation) and l-cysteine (reduction). This Janus system provides a new paradigm for the design of biochemically responsive MRI contrast agents.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Quelantes
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Peroxidase
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Meios de Contraste
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Cisteína
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Manganês
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos